fbpx
T. +32 (0)53 72 90 28 fr | +32 (0)53 72 90 20 nl|info@zoolyx.be

Espèces et références

Bovin

5 - 18

U/L

Chat

<109

U/L

Chien

<117

U/L

Chèvre

<52

U/L

Dauphin

U/L

Furet

U/L

Lapin

<70

U/L

Mouton

<44

U/L

Oiseau

U/L

Phoque

U/L

Porc

19 - 76

U/L

Reptile

U/L

Caractéristiques

Abbréviation

ALT

Catégorie

Foie-voies biliaires

LOINC

Méthode

UV without P5P

Délai

le même jour

Prélèvement

*

Sérum

 

EDTA plasma

 

Li-Héparinisé plasma

* = préférence


Synonymes

  • ALAT, alanine aminotransférase
  • (S)GPT, (serum) glutamaat-pyruvaat transaminase
  • EC 2.6.1.2

Physiologie

L’alanine aminotransférase catalyse le transfert du groupe alpha-amino de l’alanine à l’oxoglutarate avec production de pyruvate et de glutamate. L’ALT se retrouve principalement dans le cytoplasme (et seulement en petites quantités dans les mitochondries). Pour une activité optimale, comme l’AST, cet enzyme nécessite le cofacteur P5P.

Spécificité

  • L’ALT est présent dans le tissu hépatique, musculaire (coeur et squelettique), rénale et les globules rouges.
  • L’ALT est assez spécifique pour le foie chez le chien chat, furet, et primates. A un moindre degré chez le lapin et les rongeurs.
  • Le tissu hépatique chez des grandes herbivores et porcine contient une activité enzymatique faible limitant l’utilité.
  • L’ALT est peu spécifique pour le foie aviaire et reptilien.

Sensibilité

  • Haute pour l’inflammation, la nécrose, la lipidose  et le néoplasme primaire hépatique.
  • Plus faible pour la congestion, le néoplasme métastique ou les anomalies vasculaires portosystémique.

Contenu caché

Login

Références

1.
Valentine B, Blue J, Shelley S, Cooper B. Increased serum alanine aminotransferase activity associated with muscle necrosis in the dog. J Vet Intern Med. 1990;4(3):140-143. [PubMed]
2.
Swenson C, Graves T. Absence of liver specificity for canine alanine aminotransferase (ALT). Vet Clin Pathol. 1997;26(1):26-28. [PubMed]
3.
Sorensen K, Venn-Watson S, Ridgway S. Trace and non-trace elements in blood cells of bottlenose dolphins (Tursiops truncatus): variations with values from liver function indicators. J Wildl Dis. 2008;44(2):304-317. [PubMed]
4.
Venn-Watson S, Smith C, Jensen E. Assessment of increased serum aminotransferases in a managed Atlantic bottlenose dolphin (Tursiops truncatus) population. J Wildl Dis. 2008;44(2):318-330. [PubMed]
5.
Fauquier D, Mazet J, Gulland F, Spraker T, Christopher M. Distribution of tissue enzymes in three species of pinnipeds. J Zoo Wildl Med. 2008;39(1):1-5. [PubMed]
6.
Jerry Kaneko J, W. Harvey J, L. Bruss M. Clinical Biochemistry of Domestic Animals. Academic Press; 2008.
7.
Quesenberry K, W. Carpenter J. Ferrets, Rabbits and Rodents - E-Book. Elsevier Health Sciences; 2011.
8.
Montalvo V, Cruz M, Ahmad I, et al. Hepatitis E virus in bottlenose dolphins Tursiops truncatus. Dis Aquat Organ. 2017;123(1):13-18. [PubMed]

Récement sur pubmed

Chien

  1. Bajwa, J, Charach, M, Duclos, D. Adverse effects of rifampicin in dogs and serum alanine aminotransferase monitoring recommendations based on a retrospective study of 344 dogs. Vet Dermatol. 2013;24 (6):570-5, e135-6. doi: 10.1111/vde.12083. PubMed PMID:24164464 .
  2. Herzog, E, Pragst, I, Waelchli, M, Gille, A, Schenk, S, Mueller-Cohrs, J et al.. Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component. J Appl Toxicol. 2016;36 (8):1038-47. doi: 10.1002/jat.3264. PubMed PMID:26651060 .
  3. Myburgh, EC, Goddard, A. The effect of pyridoxal-5-phosphate on serum alanine aminotransferase activity in dogs suffering from canine babesiosis. Onderstepoort J Vet Res. 2009;76 (3):327-33. doi: 10.4102/ojvr.v76i3.38. PubMed PMID:21105601 .
  4. Miyazaki, M, Rosenblum, JS, Kasahara, Y, Nakagawa, I, Patricelli, MP. Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury. J Pharmacol Toxicol Methods. ;60 (3):307-15. doi: 10.1016/j.vascn.2009.09.001. PubMed PMID:19748590 .
  5. Rajamohan, F, Nelms, L, Joslin, DL, Lu, B, Reagan, WJ, Lawton, M et al.. cDNA cloning, expression, purification, distribution, and characterization of biologically active canine alanine aminotransferase-1. Protein Expr Purif. 2006;48 (1):81-9. doi: 10.1016/j.pep.2005.12.009. PubMed PMID:16495081 .
  6. El-Sebaey, AM, Abramov, PN. Hepatocyte-derived canine familiaris-microRNAs as serum biomarkers of hepatic steatosis or fibrosis as implicated in the pathogenesis of canine cholecystolithiasis. Vet Clin Pathol. 2022;50 Suppl 1 :37-46. doi: 10.1111/vcp.12942. PubMed PMID:34031917 .
  7. Geffré, A, Braun, JP, Germain, C, Palanché, F, Kueper, R, Trumel, C et al.. Comparison of measurements of canine plasma glucose, creatinine, urea, total proteins, alanine aminotransferase, and alkaline phosphatase obtained with the APOLOWAKO and Vitros 250 analyzers. Res Vet Sci. 2008;84 (3):354-60. doi: 10.1016/j.rvsc.2007.07.001. PubMed PMID:17826812 .
  8. Menard, M, Lecoindre, A, Cadoré, JL, Chevallier, M, Pagnon, A, Hernandez, J et al.. Use of serum biomarkers in staging of canine hepatic fibrosis. J Vet Diagn Invest. 2019;31 (5):665-673. doi: 10.1177/1040638719866881. PubMed PMID:31347473 PubMed Central PMC6727106.
  9. Bennaim, M, Centola, S, Ramsey, I, Seth, M. Clinical and Clinicopathological Features in Dogs with Uncomplicated Spontaneous Hyperadrenocorticism Diagnosed in Primary Care Practice (2013-2014). J Am Anim Hosp Assoc. ;55 (4):178-186. doi: 10.5326/JAAHA-MS-6789. PubMed PMID:31099602 .
  10. Quantz, JE, Miles, MS, Reed, AL, White, GA. Elevation of alanine transaminase and gallbladder wall abnormalities as biomarkers of anaphylaxis in canine hypersensitivity patients. J Vet Emerg Crit Care (San Antonio). 2009;19 (6):536-44. doi: 10.1111/j.1476-4431.2009.00474.x. PubMed PMID:20017759 .
Search PubMed

Chat

  1. Armstrong, SK, Oosthuyzen, W, Gow, AG, Salavati Schmitz, S, Dear, JW, Mellanby, RJ et al.. Investigation of a relationship between serum concentrations of microRNA-122 and alanine aminotransferase activity in hospitalised cats. J Feline Med Surg. 2022; :1098612X221100071. doi: 10.1177/1098612X221100071. PubMed PMID:35703473 .
  2. Hermans, M, Charalambous, M, Pakozdy, A, Eisl-Glantschnigg, U, Neßler, J, Van Meervenne, SA et al.. Evaluation of the effect of phenobarbital administration on the biochemistry profile, with a focus on serum liver values, in epileptic cats. J Feline Med Surg. 2022;24 (6):530-538. doi: 10.1177/1098612X211037431. PubMed PMID:34387120 .
  3. Takano, T, Katoh, Y, Doki, T, Hohdatsu, T. Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo. Antiviral Res. 2013;99 (2):100-7. doi: 10.1016/j.antiviral.2013.04.016. PubMed PMID:23648708 PubMed Central PMC7114111.
  4. Ramos, DG, Santos, AR, Freitas, LD, Braga, ÍA, Silva, EP, Soares, LM et al.. Feline platynosomiasis: analysis of the association of infection levels with pathological and biochemical findings. Rev Bras Parasitol Vet. ;26 (1):54-59. doi: 10.1590/S1984-29612017009. PubMed PMID:28327881 .
  5. Mazaki-Tovi, M, Abood, SK, Segev, G, Schenck, PA. Alterations in adipokines in feline hepatic lipidosis. J Vet Intern Med. ;27 (2):242-9. doi: 10.1111/jvim.12055. PubMed PMID:23480841 .
  6. Nájera, F, Hearn, AJ, Ross, J, Nathan, S, Revuelta, L. Alterations in selected serum biochemistry values of free-ranging Bornean leopard cats (Prionailurus bengalensis borneoensis) captured by box traps. Vet Res Commun. 2014;38 (3):265-9. doi: 10.1007/s11259-014-9605-2. PubMed PMID:24839119 .
  7. Merrick, CH, Pierro, J, Schleis, SE, Sones, EA, Wright, ZM, Regan, RC et al.. Retrospective evaluation of toceranib phosphate (Palladia®) toxicity in cats. Vet Comp Oncol. 2017;15 (3):710-717. doi: 10.1111/vco.12211. PubMed PMID:27041701 .
  8. Park, DS, Lee, J, Song, KH, Seo, KW. Treatment of acute erythroleukaemia with high-dose cytarabine in a cat with feline leukaemia virus infection. Vet Med Sci. 2022;8 (1):9-13. doi: 10.1002/vms3.646. PubMed PMID:34599794 PubMed Central PMC8788972.
  9. Sunpongsri, S, Kovitvadhi, A, Rattanasrisomporn, J, Trisaksri, V, Jensirisak, N, Jaroensong, T et al.. Effectiveness and Adverse Events of Cyclophosphamide, Vincristine, and Prednisolone Chemotherapy in Feline Mediastinal Lymphoma Naturally Infected with Feline Leukemia Virus. Animals (Basel). 2022;12 (7):. doi: 10.3390/ani12070900. PubMed PMID:35405890 PubMed Central PMC8997098.
  10. Vester, BM, Burke, SL, Liu, KJ, Dikeman, CL, Simmons, LG, Swanson, KS et al.. Influence of feeding raw or extruded feline diets on nutrient digestibility and nitrogen metabolism of African wildcats (Felis lybica). Zoo Biol. ;29 (6):676-86. doi: 10.1002/zoo.20305. PubMed PMID:20095004 .
Search PubMed