Kort
Fructosamines zijn eiwitten (in hoofdzaak albumine) waar glucose op onomkeerbare wijze aan gebonden is. De concentratie ervan weerspiegelt de bloedglucoseconcentratie over de afgelopen weken en is daarmee een tool in de opvolging van diabetes mellitus.
Diersoorten en referenties
Ezel
µmol/L
Fret
125 - 200
µmol/L
Hond
µmol/L
Normaal: 244 - 376
Diabetes nieuwe diagnose >400
Diabetescontrole
Goed <450
Matig <550
Slecht >550
Kat
µmol/L
Normaal: 222 - 359
Diabetes nieuwe diagnose >400
Diabetescontrole
Goed <450
Matig <550
Slecht >550
Konijn
µmol/L
Paard
281 - 374
µmol/L
Rund
µmol/L
Kenmerken
Afkorting
FRA
Rubriek
Glucose
LOINC
Methode
Colorimetric
Doorlooptijd
dezelfde dag
Staalname
*
Serum
EDTA plasma
Li-Heparine plasma
* = voorkeur
Laatst geupdate op 31 oktober 2026 om 01:01
Referenties
1.
Thoresen S, Bredal W. Clinical usefulness of fructosamine measurements in diagnosing and monitoring feline diabetes mellitus. J Small Anim Pract. 1996;37(2):64-68. [PubMed]
2.
Crenshaw K, Peterson M, Heeb L, Moroff S, Nichols R. Serum fructosamine concentration as an index of glycemia in cats with diabetes mellitus and stress hyperglycemia. J Vet Intern Med. 1996;10(6):360-364. [PubMed]
3.
Lutz T, Rand J, Ryan E. Fructosamine concentrations in hyperglycemic cats. Can Vet J. 1995;36(3):155-159. [PubMed]
4.
Loste A, Marca M, Pérez M, Unzueta A. Clinical value of fructosamine measurements in non-healthy dogs. Vet Res Commun. 2001;25(2):109-115. [PubMed]
5.
Mellanby R, Herrtage M. Insulinoma in a normoglycaemic dog with low serum fructosamine. J Small Anim Pract. 2002;43(11):506-508. [PubMed]
6.
Rijnberk A, S. Kooistra H. Clinical Endocrinology of Dogs and Cats. European Mathematical Society; 2010.
7.
Gilor C, Graves T, Lascelles B, Thomson A, Simpson W, Halpern D. The effects of body weight, body condition score, sex, and age on serum fructosamine concentrations in clinically healthy cats. Vet Clin Pathol. 2010;39(3):322-328. [PubMed]
8.
Reusch C, Haberer B. Evaluation of fructosamine in dogs and cats with hypo- or hyperproteinaemia, azotaemia, hyperlipidaemia and hyperbilirubinaemia. Vet Rec. 2001;148(12):370-376. [PubMed]
9.
Thoresen S, Bredal W. An evaluation of serum fructosamine as a marker of the duration of hypoproteinaemic conditions in dogs. Vet Res Commun. 1998;22(3):167-177. [PubMed]
10.
Reusch C, Tomsa K. Serum fructosamine concentration in cats with overt hyperthyroidism. J Am Vet Med Assoc. 1999;215(9):1297-1300. [PubMed]
11.
Zeugswetter F, Kleiter M, Wolfesberger B, Schwendenwein I, Miller I. Elevated fructosamine concentrations caused by IgA paraproteinemia in two dogs. J Vet Sci. 2010;11(4):359-361. [PubMed]
12.
J. Kaneko J, W. Harvey J, Bruss M. Clinical Biochemistry of Domestic Animals. Academic Press; 2008.
13.
D. Willard M, Tvedten H. Small Animal Clinical Diagnosis by Laboratory Methods. W B Saunders Company; 2004.
14.
Sonntag O, Scholer A. Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies. Ann Clin Biochem. 2001;38(Pt 4):376-385. [PubMed]
15.
Link K, Rand J. Changes in blood glucose concentration are associated with relatively rapid changes in circulating fructosamine concentrations in cats. J Feline Med Surg. 2008;10(6):583-592. [PubMed]
Recent op pubmed
Hond
- Muñoz-Prieto, A, Escribano, D, Cerón, JJ, Martínez-Subiela, S, Tvarijonaviciute, A. Glucose, fructosamine, and insulin measurements in saliva of dogs: variations after an experimental glucose administration. Domest Anim Endocrinol. 2019;66 :64-71. doi: 10.1016/j.domaniend.2018.10.002. PubMed PMID:30472034 .
- Momozawa, Y, Merveille, AC, Battaille, G, Wiberg, M, Koch, J, Willesen, JL et al.. Genome wide association study of 40 clinical measurements in eight dog breeds. Sci Rep. 2020;10 (1):6520. doi: 10.1038/s41598-020-63457-y. PubMed PMID:32300138 PubMed Central PMC7162946.
- Norris, O, Schermerhorn, T. Relationship between HbA1c, fructosamine and clinical assessment of glycemic control in dogs. PLoS One. 2022;17 (2):e0264275. doi: 10.1371/journal.pone.0264275. PubMed PMID:35213623 PubMed Central PMC8880912.
- Reusch, CE, Haberer, B. Evaluation of fructosamine in dogs and cats with hypo- or hyperproteinaemia, azotaemia, hyperlipidaemia and hyperbilirubinaemia. Vet Rec. 2001;148 (12):370-6. doi: 10.1136/vr.148.12.370. PubMed PMID:11321552 .
- Watanabe, D, Nakara, H, Akagi, K, Ishii, T, Mizuguchi, H, Nagashima, Y et al.. Oral glucose tolerance test and determination of serum fructosamine level in beagle dogs. J Toxicol Sci. 2004;29 (1):33-6. doi: 10.2131/jts.29.33. PubMed PMID:15018152 .
- Jensen, AL, Aaes, H, Iversen, L, Petersen, TK. The long-term biological variability of fasting plasma glucose and serum fructosamine in healthy Beagle dogs. Vet Res Commun. 1999;23 (2):73-80. doi: 10.1023/a:1006274717184. PubMed PMID:10359151 .
- Gomez-Fernandez-Blanco, C, Peeters, D, Moyse, E, Farnir, F, Höglund, K, Gouni, V et al.. Interbreed variation of biomarkers of lipid and glucose metabolism in dogs. Vet Clin Pathol. 2018;47 (4):582-588. doi: 10.1111/vcp.12673. PubMed PMID:30556915 .
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- Reusch, CE, Gerber, B, Boretti, FS. Serum fructosamine concentrations in dogs with hypothyroidism. Vet Res Commun. 2002;26 (7):531-6. doi: 10.1023/a:1020287430949. PubMed PMID:12416867 .
- Loste, A, Marca, MC. Fructosamine and glycated hemoglobin in the assessment of glycaemic control in dogs. Vet Res. 2001;32 (1):55-62. doi: 10.1051/vetres:2001109. PubMed PMID:11254177 .
Kat
- Berman, CF, Lobetti, RG, Zini, E, Fosgate, GT, Schoeman, JP. Influence of high-protein and high-carbohydrate diets on serum lipid and fructosamine concentrations in healthy cats. J Feline Med Surg. 2022;24 (8):759-769. doi: 10.1177/1098612X211047062. PubMed PMID:34605307 PubMed Central PMC10812288.
- Hadd, MJ, Bienhoff, SE, Little, SE, Geller, S, Ogne-Stevenson, J, Dupree, TJ et al.. Safety and effectiveness of the sodium-glucose cotransporter inhibitor bexagliflozin in cats newly diagnosed with diabetes mellitus. J Vet Intern Med. 2023;37 (3):915-924. doi: 10.1111/jvim.16730. PubMed PMID:37148170 PubMed Central PMC10229323.
- Reusch, CE, Haberer, B. Evaluation of fructosamine in dogs and cats with hypo- or hyperproteinaemia, azotaemia, hyperlipidaemia and hyperbilirubinaemia. Vet Rec. 2001;148 (12):370-6. doi: 10.1136/vr.148.12.370. PubMed PMID:11321552 .
- Pérez-López, L, Boronat, M, Melián, C, Brito-Casillas, Y, Wägner, AM. Kidney function and glucose metabolism in overweight and obese cats. Vet Q. 2020;40 (1):132-139. doi: 10.1080/01652176.2020.1759844. PubMed PMID:32315583 PubMed Central PMC7241541.
- Boari, A, Aste, G, Rocconi, F, Dalessandri, A, Vita, S. Glargine insulin and high-protein-low-carbohydrate diet in cats with diabetes mellitus. Vet Res Commun. 2008;32 Suppl 1 :S243-5. doi: 10.1007/s11259-008-9119-x. PubMed PMID:18685984 .
- Lutz, TA, Rand, JS, Ryan, E. Fructosamine concentrations in hyperglycemic cats. Can Vet J. 1995;36 (3):155-9. . PubMed PMID:7757920 PubMed Central PMC1686902.
- Benedict, SL, Mahony, OM, McKee, TS, Bergman, PJ. Evaluation of bexagliflozin in cats with poorly regulated diabetes mellitus. Can J Vet Res. 2022;86 (1):52-58. . PubMed PMID:34975223 PubMed Central PMC8697324.
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- Kieler, IN, Osto, M, Hugentobler, L, Puetz, L, Gilbert, MTP, Hansen, T et al.. Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria. Sci Rep. 2019;9 (1):4822. doi: 10.1038/s41598-019-41195-0. PubMed PMID:30886210 PubMed Central PMC6423039.
- Kennedy, A, White, J, Lam, A, Kenny, P. Hypersomatotropism in diabetic cats in Australia. J Feline Med Surg. 2025;27 (11):1098612X251379726. doi: 10.1177/1098612X251379726. PubMed PMID:41215559 PubMed Central PMC12605907.
Paard
- Ribeiro, RM, Ribeiro, DS, Cota, LO, Leme, FO, M Carvalho, A, Faleiros, RR et al.. Changes in metabolic and physiological biomarkers in Mangalarga Marchador horses with induced obesity. Vet J. 2021;270 :105627. doi: 10.1016/j.tvjl.2021.105627. PubMed PMID:33641803 .
- Knowles, EJ, Menzies-Gow, NJ, Mair, TS. Plasma fructosamine concentrations in horses with pituitary pars intermedia dysfunction with and without laminitis. Equine Vet J. 2014;46 (2):249-51. doi: 10.1111/evj.12090. PubMed PMID:23663105 .
- Knowles, EJ, Withers, JM, Mair, TS. Increased plasma fructosamine concentrations in laminitic horses. Equine Vet J. 2012;44 (2):226-9. doi: 10.1111/j.2042-3306.2011.00419.x. PubMed PMID:21696439 .
- Staudacher, G. [Fructosamine as a valuable criterion for the evaluation of diabetic animals and its photometric determination]. Tierarztl Prax. 1990;18 (5):441-6. . PubMed PMID:2264046 .
- Murphy, D, Reid, SW, Graham, PA, Love, S. Fructosamine measurement in ponies: validation and response following experimental cyathostome infection. Res Vet Sci. 1997;63 (2):113-8. doi: 10.1016/s0034-5288(97)90002-3. PubMed PMID:9429242 .
- Satué, K, Marcilla, M, Medica, P, Cravana, C, Fazio, E. Temporal relationships of GH, IGF-I and fructosamine concentrations in pregnant Spanish Purebred mares: A substantial contribution from the hormonal standpoint. Theriogenology. 2018;118 :164-171. doi: 10.1016/j.theriogenology.2018.05.040. PubMed PMID:29909261 .
- Filipović, N, Stojević, Z, Prvanović, N. Serum fructosamine concentrations in relation to metabolic changes during late pregnancy and early lactation in mares. Berl Munch Tierarztl Wochenschr. 2010;123 (3-4):169-73. . PubMed PMID:20329650 .
- Gehlen, H, Twickel, S, Stöckle, S, Weber, C, Bartmann, CP. Diagnostic orientation values for ACTH and other parameters for clinically healthy donkeys and mules (insulin, triglycerides, glucose, fructosamines, and ɣ-GT). J Anim Physiol Anim Nutr (Berl). 2020;104 (2):679-689. doi: 10.1111/jpn.13279. PubMed PMID:31900994 .
- Satué, K, Fazio, E, Velasco-Martínez, MG, Barbiera, G, La Fauci, D. Differential profiles of GH, IGF-1, and fructosamine in follicular fluid and plasma of cyclic mares. Domest Anim Endocrinol. 2026;95 :107000. doi: 10.1016/j.domaniend.2026.107000. PubMed PMID:41666841 .
- Murphy, D, Love, S. The pathogenic effects of experimental cyathostome infections in ponies. Vet Parasitol. 1997;70 (1-3):99-110. doi: 10.1016/s0304-4017(96)01153-3. PubMed PMID:9195714 .