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Fructosamine – Glucose

Kort

Fructosamines zijn eiwitten (in hoofdzaak albumine) waar glucose op onomkeerbare wijze aan gebonden is. De concentratie ervan weerspiegelt de bloedglucoseconcentratie over de afgelopen weken en is daarmee een tool in de opvolging van diabetes mellitus.

Diersoorten en referenties

Ezel

µmol/L

Fret

125 - 200

µmol/L

Hond

µmol/L

Normaal: 244 - 376
Diabetes nieuwe diagnose >400
Diabetescontrole
Goed <450
Matig <550
Slecht >550

Kat

µmol/L

Normaal: 222 - 359
Diabetes nieuwe diagnose >400
Diabetescontrole
Goed <450
Matig <550
Slecht >550

Konijn

µmol/L

Paard

281 - 374

µmol/L

Rund

µmol/L

Kenmerken

Afkorting

FRA

Rubriek

Glucose

LOINC

Methode

Colorimetric

Doorlooptijd

dezelfde dag

Staalname

*

Serum

 

EDTA plasma

 

Li-Heparine plasma

* = voorkeur


Laatst geupdate op 9 januari 2023 om 01:00

Referenties

1.
Thoresen S, Bredal W. Clinical usefulness of fructosamine measurements in diagnosing and monitoring feline diabetes mellitus. J Small Anim Pract. 1996;37(2):64-68. [PubMed]
2.
Crenshaw K, Peterson M, Heeb L, Moroff S, Nichols R. Serum fructosamine concentration as an index of glycemia in cats with diabetes mellitus and stress hyperglycemia. J Vet Intern Med. 1996;10(6):360-364. [PubMed]
3.
Lutz T, Rand J, Ryan E. Fructosamine concentrations in hyperglycemic cats. Can Vet J. 1995;36(3):155-159. [PubMed]
4.
Loste A, Marca M, Pérez M, Unzueta A. Clinical value of fructosamine measurements in non-healthy dogs. Vet Res Commun. 2001;25(2):109-115. [PubMed]
5.
Mellanby R, Herrtage M. Insulinoma in a normoglycaemic dog with low serum fructosamine. J Small Anim Pract. 2002;43(11):506-508. [PubMed]
6.
Rijnberk A, S. Kooistra H. Clinical Endocrinology of Dogs and Cats. European Mathematical Society; 2010.
7.
Gilor C, Graves T, Lascelles B, Thomson A, Simpson W, Halpern D. The effects of body weight, body condition score, sex, and age on serum fructosamine concentrations in clinically healthy cats. Vet Clin Pathol. 2010;39(3):322-328. [PubMed]
8.
Reusch C, Haberer B. Evaluation of fructosamine in dogs and cats with hypo- or hyperproteinaemia, azotaemia, hyperlipidaemia and hyperbilirubinaemia. Vet Rec. 2001;148(12):370-376. [PubMed]
9.
Thoresen S, Bredal W. An evaluation of serum fructosamine as a marker of the duration of hypoproteinaemic conditions in dogs. Vet Res Commun. 1998;22(3):167-177. [PubMed]
10.
Reusch C, Tomsa K. Serum fructosamine concentration in cats with overt hyperthyroidism. J Am Vet Med Assoc. 1999;215(9):1297-1300. [PubMed]
11.
Zeugswetter F, Kleiter M, Wolfesberger B, Schwendenwein I, Miller I. Elevated fructosamine concentrations caused by IgA paraproteinemia in two dogs. J Vet Sci. 2010;11(4):359-361. [PubMed]
12.
J. Kaneko J, W. Harvey J, Bruss M. Clinical Biochemistry of Domestic Animals. Academic Press; 2008.
13.
D. Willard M, Tvedten H. Small Animal Clinical Diagnosis by Laboratory Methods. W B Saunders Company; 2004.
14.
Sonntag O, Scholer A. Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies. Ann Clin Biochem. 2001;38(Pt 4):376-385. [PubMed]
15.
Link K, Rand J. Changes in blood glucose concentration are associated with relatively rapid changes in circulating fructosamine concentrations in cats. J Feline Med Surg. 2008;10(6):583-592. [PubMed]

Recent op pubmed

Hond

  1. Norris, O, Schermerhorn, T. Relationship between HbA1c, fructosamine and clinical assessment of glycemic control in dogs. PLoS One. 2022;17 (2):e0264275. doi: 10.1371/journal.pone.0264275. PubMed PMID:35213623 PubMed Central PMC8880912.
  2. Muñoz-Prieto, A, Escribano, D, Cerón, JJ, Martínez-Subiela, S, Tvarijonaviciute, A. Glucose, fructosamine, and insulin measurements in saliva of dogs: variations after an experimental glucose administration. Domest Anim Endocrinol. 2019;66 :64-71. doi: 10.1016/j.domaniend.2018.10.002. PubMed PMID:30472034 .
  3. Reusch, CE, Haberer, B. Evaluation of fructosamine in dogs and cats with hypo- or hyperproteinaemia, azotaemia, hyperlipidaemia and hyperbilirubinaemia. Vet Rec. 2001;148 (12):370-6. doi: 10.1136/vr.148.12.370. PubMed PMID:11321552 .
  4. Ottka, C, Puurunen, J, Müller, E, Weber, C, Klein, R, Lohi, H et al.. Metabolic changes associated with two endocrine abnormalities in dogs: elevated fructosamine and low thyroxine. Metabolomics. 2022;18 (8):58. doi: 10.1007/s11306-022-01917-4. PubMed PMID:35859216 PubMed Central PMC9300525.
  5. Loste, A, Marca, MC. Fructosamine and glycated hemoglobin in the assessment of glycaemic control in dogs. Vet Res. 2001;32 (1):55-62. doi: 10.1051/vetres:2001109. PubMed PMID:11254177 .
  6. Baldo, FD, Magna, L, Dondi, F, Maramieri, P, Catrina, OM, Corradini, S et al.. Comparison of serum fructosamine and glycated hemoglobin values for assessment of glycemic control in dogs with diabetes mellitus. Am J Vet Res. 2020;81 (3):233-242. doi: 10.2460/ajvr.81.3.233. PubMed PMID:32101039 .
  7. Bertalan, AV, Drobatz, KJ, Hess, RS. Effects of treatment with lispro and neutral protamine Hagedorn insulins on serum fructosamine and postprandial blood glucose concentrations in dogs with clinically well-controlled diabetes mellitus and postprandial hyperglycemia. Am J Vet Res. 2020;81 (2):153-158. doi: 10.2460/ajvr.81.2.153. PubMed PMID:31985281 .
  8. Reusch, CE, Liehs, MR, Hoyer, M, Vochezer, R. Fructosamine. A new parameter for diagnosis and metabolic control in diabetic dogs and cats. J Vet Intern Med. 1993;7 (3):177-82. doi: 10.1111/j.1939-1676.1993.tb03183.x. PubMed PMID:8331612 .
  9. Han, Q, Sun, J, Xie, W, Bai, Y, Wang, S, Huang, J et al.. Repeated Low-Dose Streptozotocin and Alloxan Induced Long-Term and Stable Type 1 Diabetes Model in Beagle Dogs. Biomed Res Int. 2022;2022 :5422287. doi: 10.1155/2022/5422287. PubMed PMID:35978645 PubMed Central PMC9377912.
  10. Zeugswetter, FK, Beer, R, Schwendenwein, I. Evaluation of fructosamine concentration as an index marker for glycaemic control in diabetic dogs. Vet Rec. 2022;190 (2):e244. doi: 10.1002/vetr.244. PubMed PMID:33870504 .
Search PubMed

Kat

  1. Hadd, MJ, Bienhoff, SE, Little, SE, Geller, S, Ogne-Stevenson, J, Dupree, TJ et al.. Safety and effectiveness of the sodium-glucose cotransporter inhibitor bexagliflozin in cats newly diagnosed with diabetes mellitus. J Vet Intern Med. 2023;37 (3):915-924. doi: 10.1111/jvim.16730. PubMed PMID:37148170 PubMed Central PMC10229323.
  2. Benedict, SL, Mahony, OM, McKee, TS, Bergman, PJ. Evaluation of bexagliflozin in cats with poorly regulated diabetes mellitus. Can J Vet Res. 2022;86 (1):52-58. . PubMed PMID:34975223 PubMed Central PMC8697324.
  3. Hoenig, M, Clark, M, Schaeffer, DJ, Reiche, D. Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. J Vet Pharmacol Ther. 2018;41 (2):266-273. doi: 10.1111/jvp.12467. PubMed PMID:29139146 .
  4. Berman, CF, Lobetti, RG, Zini, E, Fosgate, GT, Schoeman, JP. Influence of high-protein and high-carbohydrate diets on serum lipid and fructosamine concentrations in healthy cats. J Feline Med Surg. 2022;24 (8):759-769. doi: 10.1177/1098612X211047062. PubMed PMID:34605307 PubMed Central PMC10812288.
  5. Reusch, CE, Haberer, B. Evaluation of fructosamine in dogs and cats with hypo- or hyperproteinaemia, azotaemia, hyperlipidaemia and hyperbilirubinaemia. Vet Rec. 2001;148 (12):370-6. doi: 10.1136/vr.148.12.370. PubMed PMID:11321552 .
  6. Pérez-López, L, Boronat, M, Melián, C, Brito-Casillas, Y, Wägner, AM. Kidney function and glucose metabolism in overweight and obese cats. Vet Q. 2020;40 (1):132-139. doi: 10.1080/01652176.2020.1759844. PubMed PMID:32315583 PubMed Central PMC7241541.
  7. Reusch, CE, Liehs, MR, Hoyer, M, Vochezer, R. Fructosamine. A new parameter for diagnosis and metabolic control in diabetic dogs and cats. J Vet Intern Med. 1993;7 (3):177-82. doi: 10.1111/j.1939-1676.1993.tb03183.x. PubMed PMID:8331612 .
  8. Crenshaw, KL, Peterson, ME, Heeb, LA, Moroff, SD, Nichols, R. Serum fructosamine concentration as an index of glycemia in cats with diabetes mellitus and stress hyperglycemia. J Vet Intern Med. 1996;10 (6):360-4. doi: 10.1111/j.1939-1676.1996.tb02081.x. PubMed PMID:8947867 .
  9. Hoenig, M, Traas, AM, Schaeffer, DJ. Evaluation of routine hematology profile results and fructosamine, thyroxine, insulin, and proinsulin concentrations in lean, overweight, obese, and diabetic cats. J Am Vet Med Assoc. 2013;243 (9):1302-9. doi: 10.2460/javma.243.9.1302. PubMed PMID:24134581 .
  10. Kieler, IN, Osto, M, Hugentobler, L, Puetz, L, Gilbert, MTP, Hansen, T et al.. Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria. Sci Rep. 2019;9 (1):4822. doi: 10.1038/s41598-019-41195-0. PubMed PMID:30886210 PubMed Central PMC6423039.
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Paard

  1. Knowles, EJ, Menzies-Gow, NJ, Mair, TS. Plasma fructosamine concentrations in horses with pituitary pars intermedia dysfunction with and without laminitis. Equine Vet J. 2014;46 (2):249-51. doi: 10.1111/evj.12090. PubMed PMID:23663105 .
  2. Ribeiro, RM, Ribeiro, DS, Cota, LO, Leme, FO, M Carvalho, A, Faleiros, RR et al.. Changes in metabolic and physiological biomarkers in Mangalarga Marchador horses with induced obesity. Vet J. 2021;270 :105627. doi: 10.1016/j.tvjl.2021.105627. PubMed PMID:33641803 .
  3. Murphy, D, Reid, SW, Graham, PA, Love, S. Fructosamine measurement in ponies: validation and response following experimental cyathostome infection. Res Vet Sci. 1997;63 (2):113-8. doi: 10.1016/s0034-5288(97)90002-3. PubMed PMID:9429242 .
  4. Gehlen, H, Twickel, S, Stöckle, S, Weber, C, Bartmann, CP. Diagnostic orientation values for ACTH and other parameters for clinically healthy donkeys and mules (insulin, triglycerides, glucose, fructosamines, and ɣ-GT). J Anim Physiol Anim Nutr (Berl). 2020;104 (2):679-689. doi: 10.1111/jpn.13279. PubMed PMID:31900994 .
  5. Knowles, EJ, Withers, JM, Mair, TS. Increased plasma fructosamine concentrations in laminitic horses. Equine Vet J. 2012;44 (2):226-9. doi: 10.1111/j.2042-3306.2011.00419.x. PubMed PMID:21696439 .
  6. Satué, K, Marcilla, M, Medica, P, Cravana, C, Fazio, E. Temporal relationships of GH, IGF-I and fructosamine concentrations in pregnant Spanish Purebred mares: A substantial contribution from the hormonal standpoint. Theriogenology. 2018;118 :164-171. doi: 10.1016/j.theriogenology.2018.05.040. PubMed PMID:29909261 .
  7. Murphy, D, Love, S. The pathogenic effects of experimental cyathostome infections in ponies. Vet Parasitol. 1997;70 (1-3):99-110. doi: 10.1016/s0304-4017(96)01153-3. PubMed PMID:9195714 .
  8. Filipović, N, Stojević, Z, Prvanović, N. Serum fructosamine concentrations in relation to metabolic changes during late pregnancy and early lactation in mares. Berl Munch Tierarztl Wochenschr. 2010;123 (3-4):169-73. . PubMed PMID:20329650 .
  9. Keen, JA, McLaren, M, Chandler, KJ, McGorum, BC. Biochemical indices of vascular function, glucose metabolism and oxidative stress in horses with equine Cushing's disease. Equine Vet J. 2004;36 (3):226-9. doi: 10.2746/0425164044877215. PubMed PMID:15147129 .
  10. Staudacher, G. [Fructosamine as a valuable criterion for the evaluation of diabetic animals and its photometric determination]. Tierarztl Prax. 1990;18 (5):441-6. . PubMed PMID:2264046 .
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