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Diersoorten en referenties

Ezel

µmol/L

Fret

125 - 200

µmol/L

Hond

µmol/L

Normaal: 244 - 376
Diabetes nieuwe diagnose >400
Diabetescontrole
Goed <450
Matig <550
Slecht >550

Kat

µmol/L

Normaal: 222 - 359
Diabetes nieuwe diagnose >400
Diabetescontrole
Goed <450
Matig <550
Slecht >550

Konijn

µmol/L

Paard

281 - 374

µmol/L

Rund

µmol/L

Kenmerken

Afkorting

FRA

Rubriek

Glucose

LOINC

Methode

Colorimetric

Doorlooptijd

dezelfde dag

Staalname

*

Serum

 

EDTA plasma

 

Li-Heparine plasma

* = voorkeur


Fysiologie

Fructosamines zijn het resultaat van een irreversiebele, niet-enzymatische, insuline-onafhankelijke binding van glucose aan serumeiwitten. De mate van glycolysatie van serumeiwitten is rechtstreeks gerelateerd aan de bloedglucoseconcentratie. Hoe hoger de gemiddelde glucoseconcentratie gedurende een langere periode hoe hoger de fructosamineconcentratie en omgekeerd.

De reactie van de fructosamineconcentratie op hyperglycemie blijkt bij katten wel sneller op te treden dan de 2-3w die geëxtrapoleerd wordt uit de humane geneeskunde. Na het kunstmatig induceren van een sterke hyperglycemie dmv glucoseinfusie duurt het 3-5d eer fructosamine duidelijk verhoogd, bereikt na 20d een plateau, en normaliseert 5d na het stopzetten van infusie. Wanneer de hyperglycemie maar matig is, duurt het langer eer het verhoogd is, bereikt eerder een plateau en normaliseert reeds 1d na het stopzetten van infusie.


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Referenties

1.
Thoresen S, Bredal W. Clinical usefulness of fructosamine measurements in diagnosing and monitoring feline diabetes mellitus. J Small Anim Pract. 1996;37(2):64-68. [PubMed]
2.
Crenshaw K, Peterson M, Heeb L, Moroff S, Nichols R. Serum fructosamine concentration as an index of glycemia in cats with diabetes mellitus and stress hyperglycemia. J Vet Intern Med. 1996;10(6):360-364. [PubMed]
3.
Lutz T, Rand J, Ryan E. Fructosamine concentrations in hyperglycemic cats. Can Vet J. 1995;36(3):155-159. [PubMed]
4.
Loste A, Marca M, Pérez M, Unzueta A. Clinical value of fructosamine measurements in non-healthy dogs. Vet Res Commun. 2001;25(2):109-115. [PubMed]
5.
Mellanby R, Herrtage M. Insulinoma in a normoglycaemic dog with low serum fructosamine. J Small Anim Pract. 2002;43(11):506-508. [PubMed]
6.
Rijnberk A, S. Kooistra H. Clinical Endocrinology of Dogs and Cats. European Mathematical Society; 2010.
7.
Gilor C, Graves T, Lascelles B, Thomson A, Simpson W, Halpern D. The effects of body weight, body condition score, sex, and age on serum fructosamine concentrations in clinically healthy cats. Vet Clin Pathol. 2010;39(3):322-328. [PubMed]
8.
Reusch C, Haberer B. Evaluation of fructosamine in dogs and cats with hypo- or hyperproteinaemia, azotaemia, hyperlipidaemia and hyperbilirubinaemia. Vet Rec. 2001;148(12):370-376. [PubMed]
9.
Thoresen S, Bredal W. An evaluation of serum fructosamine as a marker of the duration of hypoproteinaemic conditions in dogs. Vet Res Commun. 1998;22(3):167-177. [PubMed]
10.
Reusch C, Tomsa K. Serum fructosamine concentration in cats with overt hyperthyroidism. J Am Vet Med Assoc. 1999;215(9):1297-1300. [PubMed]
11.
Zeugswetter F, Kleiter M, Wolfesberger B, Schwendenwein I, Miller I. Elevated fructosamine concentrations caused by IgA paraproteinemia in two dogs. J Vet Sci. 2010;11(4):359-361. [PubMed]
12.
J. Kaneko J, W. Harvey J, Bruss M. Clinical Biochemistry of Domestic Animals. Academic Press; 2008.
13.
D. Willard M, Tvedten H. Small Animal Clinical Diagnosis by Laboratory Methods. W B Saunders Company; 2004.
14.
Sonntag O, Scholer A. Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies. Ann Clin Biochem. 2001;38(Pt 4):376-385. [PubMed]
15.
Link K, Rand J. Changes in blood glucose concentration are associated with relatively rapid changes in circulating fructosamine concentrations in cats. J Feline Med Surg. 2008;10(6):583-592. [PubMed]

Recent op pubmed

Hond

  1. Norris, O, Schermerhorn, T. Relationship between HbA1c, fructosamine and clinical assessment of glycemic control in dogs. PLoS One. 2022;17 (2):e0264275. doi: 10.1371/journal.pone.0264275. PubMed PMID:35213623 PubMed Central PMC8880912.
  2. Zeugswetter, FK, Beer, R, Schwendenwein, I. Evaluation of fructosamine concentration as an index marker for glycaemic control in diabetic dogs. Vet Rec. 2022;190 (2):e244. doi: 10.1002/vetr.244. PubMed PMID:33870504 .
  3. Momozawa, Y, Merveille, AC, Battaille, G, Wiberg, M, Koch, J, Willesen, JL et al.. Genome wide association study of 40 clinical measurements in eight dog breeds. Sci Rep. 2020;10 (1):6520. doi: 10.1038/s41598-020-63457-y. PubMed PMID:32300138 PubMed Central PMC7162946.
  4. Baldo, FD, Magna, L, Dondi, F, Maramieri, P, Catrina, OM, Corradini, S et al.. Comparison of serum fructosamine and glycated hemoglobin values for assessment of glycemic control in dogs with diabetes mellitus. Am J Vet Res. 2020;81 (3):233-242. doi: 10.2460/ajvr.81.3.233. PubMed PMID:32101039 .
  5. Bertalan, AV, Drobatz, KJ, Hess, RS. Effects of treatment with lispro and neutral protamine Hagedorn insulins on serum fructosamine and postprandial blood glucose concentrations in dogs with clinically well-controlled diabetes mellitus and postprandial hyperglycemia. Am J Vet Res. 2020;81 (2):153-158. doi: 10.2460/ajvr.81.2.153. PubMed PMID:31985281 .
  6. Rivera-Velez, SM, Hwang, J, Navas, J, Villarino, NF. Identification of differences in the formation of plasma glycated proteins between dogs and humans under diabetes-like glucose concentration conditions. Int J Biol Macromol. 2019;123 :1197-1203. doi: 10.1016/j.ijbiomac.2018.11.188. PubMed PMID:30465839 .
  7. Muñoz-Prieto, A, Escribano, D, Cerón, JJ, Martínez-Subiela, S, Tvarijonaviciute, A. Glucose, fructosamine, and insulin measurements in saliva of dogs: variations after an experimental glucose administration. Domest Anim Endocrinol. 2019;66 :64-71. doi: 10.1016/j.domaniend.2018.10.002. PubMed PMID:30472034 .
  8. Gomez-Fernandez-Blanco, C, Peeters, D, Moyse, E, Farnir, F, Höglund, K, Gouni, V et al.. Interbreed variation of biomarkers of lipid and glucose metabolism in dogs. Vet Clin Pathol. 2018;47 (4):582-588. doi: 10.1111/vcp.12673. PubMed PMID:30556915 .
  9. Teixeira, FA, Machado, DP, Jeremias, JT, Queiroz, MR, Pontieri, CFF, Brunetto, MA et al.. Effects of pea with barley and less-processed maize on glycaemic control in diabetic dogs. Br J Nutr. 2018;120 (7):777-786. doi: 10.1017/S000711451800171X. PubMed PMID:30132436 .
  10. Forsberg, SK, Kierczak, M, Ljungvall, I, Merveille, AC, Gouni, V, Wiberg, M et al.. The Shepherds' Tale: A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds. PLoS One. 2015;10 (5):e0123173. doi: 10.1371/journal.pone.0123173. PubMed PMID:25970163 PubMed Central PMC4430432.
Search PubMed

Kat

  1. Benedict, SL, Mahony, OM, McKee, TS, Bergman, PJ. Evaluation of bexagliflozin in cats with poorly regulated diabetes mellitus. Can J Vet Res. 2022;86 (1):52-58. . PubMed PMID:34975223 PubMed Central PMC8697324.
  2. Pérez-López, L, Boronat, M, Melián, C, Brito-Casillas, Y, Wägner, AM. Kidney function and glucose metabolism in overweight and obese cats. Vet Q. 2020;40 (1):132-139. doi: 10.1080/01652176.2020.1759844. PubMed PMID:32315583 PubMed Central PMC7241541.
  3. Williams, MC, McMillan, CJ, Snead, ER, Takada, K, Chelikani, PK. Association of circulating adipokine concentrations with indices of adiposity and sex in healthy, adult client owned cats. BMC Vet Res. 2019;15 (1):332. doi: 10.1186/s12917-019-2080-9. PubMed PMID:31533709 PubMed Central PMC6749635.
  4. Kieler, IN, Osto, M, Hugentobler, L, Puetz, L, Gilbert, MTP, Hansen, T et al.. Diabetic cats have decreased gut microbial diversity and a lack of butyrate producing bacteria. Sci Rep. 2019;9 (1):4822. doi: 10.1038/s41598-019-41195-0. PubMed PMID:30886210 PubMed Central PMC6423039.
  5. Hoenig, M, Clark, M, Schaeffer, DJ, Reiche, D. Effects of the sodium-glucose cotransporter 2 (SGLT2) inhibitor velagliflozin, a new drug with therapeutic potential to treat diabetes in cats. J Vet Pharmacol Ther. 2018;41 (2):266-273. doi: 10.1111/jvp.12467. PubMed PMID:29139146 .
  6. Gostelow, R, Scudder, C, Keyte, S, Forcada, Y, Fowkes, RC, Schmid, HA et al.. Pasireotide Long-Acting Release Treatment for Diabetic Cats with Underlying Hypersomatotropism. J Vet Intern Med. 2017;31 (2):355-364. doi: 10.1111/jvim.14662. PubMed PMID:28145031 PubMed Central PMC5354018.
  7. Hoenig, M, Traas, AM, Schaeffer, DJ. Evaluation of routine hematology profile results and fructosamine, thyroxine, insulin, and proinsulin concentrations in lean, overweight, obese, and diabetic cats. J Am Vet Med Assoc. 2013;243 (9):1302-9. doi: 10.2460/javma.243.9.1302. PubMed PMID:24134581 .
  8. Tschuor, F, Zini, E, Schellenberg, S, Wenger, M, Kaufmann, K, Furrer, D et al.. Remission of diabetes mellitus in cats cannot be predicted by the arginine stimulation test. J Vet Intern Med. ;25 (1):83-9. doi: 10.1111/j.1939-1676.2010.0649.x. PubMed PMID:21143647 .
  9. Gilor, C, Graves, TK, Lascelles, BD, Thomson, AE, Simpson, W, Halpern, DS et al.. The effects of body weight, body condition score, sex, and age on serum fructosamine concentrations in clinically healthy cats. Vet Clin Pathol. 2010;39 (3):322-8. doi: 10.1111/j.1939-165X.2010.00227.x. PubMed PMID:20412547 .
  10. Lowe, AD, Graves, TK, Campbell, KL, Schaeffer, DJ. A pilot study comparing the diabetogenic effects of dexamethasone and prednisolone in cats. J Am Anim Hosp Assoc. ;45 (5):215-24. doi: 10.5326/0450215. PubMed PMID:19723844 .
Search PubMed

Paard

  1. Ribeiro, RM, Ribeiro, DS, Cota, LO, Leme, FO, M Carvalho, A, Faleiros, RR et al.. Changes in metabolic and physiological biomarkers in Mangalarga Marchador horses with induced obesity. Vet J. 2021;270 :105627. doi: 10.1016/j.tvjl.2021.105627. PubMed PMID:33641803 .
  2. Satué, K, Marcilla, M, Medica, P, Cravana, C, Fazio, E. Temporal relationships of GH, IGF-I and fructosamine concentrations in pregnant Spanish Purebred mares: A substantial contribution from the hormonal standpoint. Theriogenology. 2018;118 :164-171. doi: 10.1016/j.theriogenology.2018.05.040. PubMed PMID:29909261 .
  3. Knowles, EJ, Menzies-Gow, NJ, Mair, TS. Plasma fructosamine concentrations in horses with pituitary pars intermedia dysfunction with and without laminitis. Equine Vet J. 2014;46 (2):249-51. doi: 10.1111/evj.12090. PubMed PMID:23663105 .
  4. Knowles, EJ, Withers, JM, Mair, TS. Increased plasma fructosamine concentrations in laminitic horses. Equine Vet J. 2012;44 (2):226-9. doi: 10.1111/j.2042-3306.2011.00419.x. PubMed PMID:21696439 .
  5. Gehlen, H, Twickel, S, Stöckle, S, Weber, C, Bartmann, CP. Diagnostic orientation values for ACTH and other parameters for clinically healthy donkeys and mules (insulin, triglycerides, glucose, fructosamines, and ɣ-GT). J Anim Physiol Anim Nutr (Berl). 2020;104 (2):679-689. doi: 10.1111/jpn.13279. PubMed PMID:31900994 .
  6. Filipović, N, Stojević, Z, Prvanović, N. Serum fructosamine concentrations in relation to metabolic changes during late pregnancy and early lactation in mares. Berl Munch Tierarztl Wochenschr. ;123 (3-4):169-73. . PubMed PMID:20329650 .
  7. Keen, JA, McLaren, M, Chandler, KJ, McGorum, BC. Biochemical indices of vascular function, glucose metabolism and oxidative stress in horses with equine Cushing's disease. Equine Vet J. 2004;36 (3):226-9. doi: 10.2746/0425164044877215. PubMed PMID:15147129 .
  8. Murphy, D, Reid, SW, Graham, PA, Love, S. Fructosamine measurement in ponies: validation and response following experimental cyathostome infection. Res Vet Sci. ;63 (2):113-8. doi: 10.1016/s0034-5288(97)90002-3. PubMed PMID:9429242 .
  9. Murphy, D, Love, S. The pathogenic effects of experimental cyathostome infections in ponies. Vet Parasitol. 1997;70 (1-3):99-110. doi: 10.1016/s0304-4017(96)01153-3. PubMed PMID:9195714 .
  10. Staudacher, G. [Fructosamine as a valuable criterion for the evaluation of diabetic animals and its photometric determination]. Tierarztl Prax. 1990;18 (5):441-6. . PubMed PMID:2264046 .
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